Abiomend Xplus Membrane (Q4355)
Abiomend Xplus Membrane is an advanced, crosslinked, chorion-free amniotic tissue designed to support wound healing and tissue regeneration. The crosslinking process makes Abiomend Xplus particularly useful in long-term wound coverage and structural support, distinguishing it from non-crosslinked amniotic membranes that degrade quicker.
CROSSLINKED FEATURES
Increased Strength & Stability: Crosslinking strengthens the extracellular matrix (ECM) by creating covalent bonds between collagen fibers, improving its mechanical properties.5
Extended Resorption Time: The process slows down the natural degradation of the tissue, allowing it to remain in the body longer for sustained therapeutic effects.3
Improved Biocompatibility: Crosslinked membranes retain essential growth factors while reducing the risk of rapid breakdown or host rejection.1,3,5
Enhanced Wound Protection: Provides a more robust and resilient barrier for wound healing and tissue regeneration.4
WHY CHOOSE ABIOMEND XPLUS?
Crosslinked: Enhances structural integrity and durability.3,5
Ethically Sourced & Safe: Donor tissues are recovered with maternal consent, using stringent screening and aseptic processing to meet FDA and CLIA standards.
Rich in Growth Factors: Contains key growth factors, cytokines, and extracellular matrix proteins vital for wound healing.1,3
Supports Natural Healing: Offers anti-inflammatory, antibacterial, and anti-fibrotic properties to promote tissue regeneration.4
Flexible & Adaptable: Provides greater tensile strength, shape manipulation, and controlled resorption for various clinical applications.3
KEY GROWTH FACTORS FOUND IN ABIOMEND XPLUS:
Fibroblast Growth Factor (FGF) 1,3
Epidermal Growth Factor (EGF) 1,3
Platelet Derived Growth Factor (PDGF) A & B 1,3
Vascular Endothelial Growth Factor (VEGF) 1,3
Transforming Growth Factor beta (TBFβ) 1,3
EXTRACELLULAR MATRIX ELEMENTS FOUND IN AMBIOMEND XPLUS:
Collagen Types I, III, IV, V and VII 4
Laminin
Fibronectin
Tissue Inhibitors of Metalloproteinases (TIMPs)
Proteoglycans
Hyaluronic Acid (HA)
APPLICATIONS:
Chronic wounds (diabetic ulcers, pressure ulcers)2
Surgical wounds
Burns and trauma wounds 2
Ophthalmic procedures
Orthopedic and sports medicine
ORDERING INFORMATION - Q4355
| CODE | DESCRIPTION |
|---|---|
| ABXM-22 | Single Layer Crosslinked Amniotic Membrane 2×2 cm |
| ABXM-23 | Single Layer Crosslinked Amniotic Membrane 2×3 cm |
| ABXM-24 | Single Layer Crosslinked Amniotic Membrane 2×4 cm |
| ABXM-44 | Single Layer Crosslinked Amniotic Membrane 4×4 cm |
| ABXM-48 | Single Layer Crosslinked Amniotic Membrane 4×8 cm |
REFERENCES:
1) Complements and the Wound Healing Cascade: An Updated Review. Hani Sinno and Satya Prakash. Plast Surg Int. 2013; 2013: 146764
2) The Grafting of Preserved Amniotic Membrane to Burned and Ulcerated Surfaces, Substituting Skin Grafts: A Preliminary Report. Maximilian Stern. JAMA. 1913; 60(13): 973-974
3) Growth factors and cytokines in wound healing. Barrientos S, Stojadinovic 0, Golinko MS, Brem H, Tomic-Canic M. Wound Repair Regen. 2008; 16(5):585-601
4) Immunological characteristics of amniotic epithelium. Hori J, Wang M, Kamiya K, Takahashi H, Sakuragawa N. Cornea. 2006; 25(10): S53-58
5) Delgado LM, Bayon Y, Pandit A, Zeugolis DI. To cross-link or not to cross-link? Cross-linking associated foreign body response of collagen-based devices. Tissue Eng Part B Rev. 2015 Jun;21(3):298-313. doi: 10.1089/ten.TEB.2014.0290. Epub 2015 Mar 12. PMID: 25517923; PMCID: PMC4442559.
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